Toll like receptor-4 gene polymorphisms in patients with solitary cysticercus granuloma

J Neurol Sci. 2015 Aug 15;355(1-2):180-5. doi: 10.1016/j.jns.2015.06.014. Epub 2015 Jun 10.


Background: Solitary cysticercus granuloma (SCG) of the brain is the most common type of neurocysticercosis in India. In this study, we evaluated TLR4 polymorphisms in patients with SCG.

Methods: One-hundred-forty-three patients with SCG and 134 controls were enrolled. Assessment for TLR4 Asp299Gly and Thr399Ile polymorphism was done. TLR4 genotype was determined by PCR-sequencing chain termination method. The patients were followed for 6 months.

Results: Asp/Gly (P=0.024) and Thr/Ile (P=0.004) genotypes were significantly associated with the SCG. The Gly (Asp/Gly plus Gly/Gly) genotype (P=0.025) and Ile (Thr/Ile plus Ile/Ile) genotype (P=0.008) were significantly associated with the SCG. Gly/Gly and Ile/Ile genotypes were not significantly associated with SCG (P=0.767 for Gly/Gly, P=0.936 for Ile/Ile). At 6 months, TLR4 299Asp/Gly (P=0.02) and 399Ile/Thr (P=0.023) polymorphisms were significantly associated with the calcification or persistence of SCG.

Conclusions: TLR4 polymorphisms are associated with the susceptibility to infection with SCG.

Keywords: Cysticercosis; Innate immunity; Neurocysticercosis; Ring enhancing lesion; Seizures; Toll-like receptors.

MeSH terms

  • Adolescent
  • Adult
  • Anticonvulsants / therapeutic use
  • Case-Control Studies
  • Child
  • Female
  • Follow-Up Studies
  • Genetic Predisposition to Disease / genetics*
  • Genetic Testing
  • Granuloma / drug therapy
  • Granuloma / etiology*
  • Granuloma / genetics*
  • Humans
  • India
  • Male
  • Neurocysticercosis / complications*
  • Polymorphism, Single Nucleotide / genetics*
  • Seizures / drug therapy
  • Seizures / etiology
  • Statistics, Nonparametric
  • Toll-Like Receptor 4 / genetics*
  • Tomography, X-Ray Computed
  • Young Adult


  • Anticonvulsants
  • Toll-Like Receptor 4