Cadmium, one of the villains behind the curtain: has exposure to cadmium helped to pull the strings of seropositive rheumatoid arthritis pathogenesis all along?

Int J Rheum Dis. 2015 Jun;18(5):570-3; quiz 574-6. doi: 10.1111/1756-185X.12673.


Exposure to cadmium links smoking, the most import antetiological factor in the development of seropositive RA, and many of the other known contemporary risk factors. Epidemiological studies investigating the link between smoking, occupations, social class, region of residency and RA should consider cadmium exposure as an important confounding factor. Studies to determine if cadmium can induce citrullination will be pivotal in determining if cadmium has indeed been the villain behind the curtain regarding the pathogenesis of seropositive RA.

MeSH terms

  • Arthritis, Rheumatoid / chemically induced*
  • Arthritis, Rheumatoid / etiology*
  • Arthritis, Rheumatoid / immunology
  • Cadmium / adverse effects*
  • Humans
  • Occupational Exposure / adverse effects
  • Risk Factors
  • Smoking / adverse effects
  • Social Class


  • Cadmium