Cladophialophora bantiana as an Emerging Pathogen in Animals: Case Report of Equine Endometritis and Review of the Literature

J Clin Microbiol. 2015 Sep;53(9):3047-53. doi: 10.1128/JCM.00728-15. Epub 2015 Jun 17.

Abstract

We present an unusual equine endometritis case associated with Cladophialophora bantiana in a 15-year-old mare. The mare displayed infertility and uterine fluid accumulation with numerous black, hairy granules. Microscopically, the fluid revealed numerous septate, dark fungal hyphae and conidia in chains. Culture yielded C. bantiana (CBS 138271); the species was confirmed by internal transcribed spacer (ITS) sequencing. Treatment was unsuccessful. C. bantiana causes cerebral phaeohyphomycosis in humans, while animal cases are rare. Animal cases are reviewed.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Animals
  • Ascomycota / classification
  • Ascomycota / genetics
  • Ascomycota / isolation & purification*
  • Cluster Analysis
  • DNA, Fungal / chemistry
  • DNA, Fungal / genetics
  • DNA, Ribosomal Spacer / chemistry
  • DNA, Ribosomal Spacer / genetics
  • Endometritis / microbiology
  • Endometritis / pathology*
  • Endometritis / veterinary*
  • Exudates and Transudates / microbiology
  • Female
  • Horse Diseases / microbiology*
  • Horse Diseases / pathology*
  • Horses
  • Microbiological Techniques
  • Microscopy
  • Molecular Sequence Data
  • Mycoses / microbiology
  • Mycoses / pathology*
  • Mycoses / veterinary*
  • Phylogeny
  • Pregnancy
  • Sequence Analysis, DNA

Substances

  • DNA, Fungal
  • DNA, Ribosomal Spacer