Comparing three toothpastes in controlling plaque and gingivitis: A 6-month clinical study

Am J Dent. 2015 Apr;28(2):68-74.


Purpose: To investigate the clinical efficacy of three toothpastes in controlling established gingivitis and plaque over 6 months.

Methods: 135 subjects were enrolled in a single-center, double-blind, parallel group, randomized clinical study. Subjects were randomly assigned to one of three treatments: triclosan/copolymer/fluoride dentifrice containing 0.3% triclosan, 2.0% copolymer and 1,450 ppm F as sodium fluoride in a silica base; herbal/bicarbonate dentifrice containing herbal extract and 1,400 ppm F as sodium fluoride in a sodium bicarbonate base; or fluoride dentifrice containing 450 ppm F as sodium fluoride, and 1,000 ppm F as sodium monofluorophosphate. Subjects were instructed to brush their teeth twice daily for 1 minute for 6 months.

Results: After 6 months, subjects assigned to the triclosan/copolymer/fluoride group exhibited statistically significant reductions in gingival index scores and plaque index scores as compared to subjects assigned to the herbal/bicarbonate group by 35.4% and 48.9%, respectively. There were no statistically significant differences in gingival index and plaque index between subjects in the herbal/ bicarbonate group and those in the fluoride group. The triclosan/copolymer/fluoride dentifrice was statistically significantly more effective in reducing gingivitis and dental plaque than the herbal/bicarbonate dentifrice, and this difference in efficacy was clinically meaningful.

Trial registration: NCT02080273.

Publication types

  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Anti-Infective Agents, Local / therapeutic use
  • Dental Plaque / prevention & control*
  • Dental Plaque Index
  • Dentifrices / therapeutic use
  • Double-Blind Method
  • Female
  • Fluorides / therapeutic use
  • Follow-Up Studies
  • Gingivitis / prevention & control*
  • Humans
  • Male
  • Middle Aged
  • Periodontal Index
  • Phosphates / therapeutic use
  • Phytotherapy / methods
  • Plant Extracts / therapeutic use
  • Sodium Bicarbonate / therapeutic use
  • Sodium Fluoride / therapeutic use
  • Toothbrushing / methods
  • Toothpastes / therapeutic use*
  • Treatment Outcome
  • Triclosan / therapeutic use
  • Young Adult


  • Anti-Infective Agents, Local
  • Dentifrices
  • Phosphates
  • Plant Extracts
  • Toothpastes
  • fluorophosphate
  • Triclosan
  • Sodium Bicarbonate
  • Sodium Fluoride
  • Fluorides

Associated data