Human Ontogeny of Drug Transporters: Review and Recommendations of the Pediatric Transporter Working Group

Clin Pharmacol Ther. 2015 Sep;98(3):266-87. doi: 10.1002/cpt.176.


The critical importance of membrane-bound transporters in pharmacotherapy is widely recognized, but little is known about drug transporter activity in children. In this white paper, the Pediatric Transporter Working Group presents a systematic review of the ontogeny of clinically relevant membrane transporters (e.g., SLC, ABC superfamilies) in intestine, liver, and kidney. Different developmental patterns for individual transporters emerge, but much remains unknown. Recommendations to increase our understanding of membrane transporters in pediatric pharmacotherapy are presented.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review
  • Systematic Review

MeSH terms

  • Age Factors
  • Animals
  • Biological Transport
  • Biomedical Research / methods
  • Child
  • Child Development
  • Child, Preschool
  • Humans
  • Infant
  • Infant, Newborn
  • Membrane Transport Proteins / metabolism*
  • Pharmaceutical Preparations / administration & dosage
  • Pharmaceutical Preparations / metabolism*
  • Pharmacokinetics


  • Membrane Transport Proteins
  • Pharmaceutical Preparations