Human induced pluripotent stem cell-derived cardiomyocytes: insights into molecular, cellular, and functional phenotypes

Circ Res. 2015 Jun 19;117(1):80-8. doi: 10.1161/CIRCRESAHA.117.305365.


Disease models are essential for understanding cardiovascular disease pathogenesis and developing new therapeutics. The human induced pluripotent stem cell (iPSC) technology has generated significant enthusiasm for its potential application in basic and translational cardiac research. Patient-specific iPSC-derived cardiomyocytes offer an attractive experimental platform to model cardiovascular diseases, study the earliest stages of human development, accelerate predictive drug toxicology tests, and advance potential regenerative therapies. Harnessing the power of iPSC-derived cardiomyocytes could eliminate confounding species-specific and interpersonal variations and ultimately pave the way for the development of personalized medicine for cardiovascular diseases. However, the predictive power of iPSC-derived cardiomyocytes as a valuable model is contingent on comprehensive and rigorous molecular and functional characterization.

Keywords: cardiovascular disease modeling; cardiovascular diseases; induced pluripotent stem cells; myocytes, cardiac; precision medicine.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Action Potentials
  • Bioengineering / methods
  • Calcium Signaling
  • Cardiovascular Diseases / pathology
  • Cations / metabolism
  • Cell Culture Techniques*
  • Cell Differentiation
  • Cell Lineage
  • Drug Evaluation, Preclinical / methods
  • Electrophysiology
  • Energy Metabolism
  • Excitation Contraction Coupling
  • Fetal Heart / cytology
  • Gene Expression Profiling
  • Humans
  • Induced Pluripotent Stem Cells / cytology*
  • Induced Pluripotent Stem Cells / drug effects
  • Induced Pluripotent Stem Cells / metabolism
  • Ion Channels / metabolism
  • Myocardial Contraction
  • Myocytes, Cardiac / classification
  • Myocytes, Cardiac / cytology*
  • Myocytes, Cardiac / metabolism
  • Myocytes, Cardiac / ultrastructure
  • Phenotype


  • Cations
  • Ion Channels