Surgery for aortic regurgitation and aortic root dilatation in Takayasu arteritis

Asian Cardiovasc Thorac Ann. 2015 Oct;23(8):901-6. doi: 10.1177/0218492315591291. Epub 2015 Jun 18.


Background: Special consideration may be required for surgical treatment in Takayasu arteritis because inflammation may cause serious complications such as valve detachment or dilatation of the residual aorta. We evaluated our surgical outcome of treatment for aortic regurgitation and aortic root dilatation in Takayasu arteritis.

Methods: Between December 1983 and January 2013, 22 cardiac operations were performed in 20 patients with aortic regurgitation due to Takayasu arteritis. Aortic valve replacement was carried out in 6 patients, and aortic root replacement in 16. Of these 16 patients, composite graft replacement was undertaken in 6, composite graft replacement plus coronary artery bypass grafting in 2, composite graft replacement plus total or partial arch replacement in 7, and valve-sparing aortic root replacement with hemiarch replacement in one.

Results: The operative mortality (within 30 days) was 4.5% and the 5-year survival rate was 90.9%. Early surgical reintervention was not required in any patient. Neither valve detachment nor composite graft detachment was noted. Two patients required redo aortic root replacement due to pseudoaneurysm formation and severe aortic regurgitation during follow-up. Late dilatation of the residual thoracoabdominal or abdominal aorta was observed in 2 patients, and both were treated surgically.

Conclusions: The early surgical outcome was acceptable but surgical reintervention was required because of late dilatation of the residual aorta or recurrent aortic regurgitation due to annular dilatation, and longstanding careful follow-up will be needed.

Keywords: Aortic arch syndromes; Aortic valve insufficiency; Arteritis; Heart valve prosthesis implantation; Takayasu arteritis; Treatment outcome.

MeSH terms

  • Adult
  • Aortic Aneurysm / diagnosis
  • Aortic Aneurysm / etiology
  • Aortic Aneurysm / mortality
  • Aortic Aneurysm / surgery*
  • Aortic Valve Insufficiency / diagnosis
  • Aortic Valve Insufficiency / etiology
  • Aortic Valve Insufficiency / mortality
  • Aortic Valve Insufficiency / surgery*
  • Blood Vessel Prosthesis Implantation* / adverse effects
  • Blood Vessel Prosthesis Implantation* / mortality
  • Female
  • Heart Valve Prosthesis Implantation* / adverse effects
  • Heart Valve Prosthesis Implantation* / mortality
  • Humans
  • Male
  • Middle Aged
  • Postoperative Complications / surgery
  • Reoperation
  • Retrospective Studies
  • Risk Factors
  • Takayasu Arteritis / complications
  • Takayasu Arteritis / diagnosis
  • Takayasu Arteritis / mortality
  • Takayasu Arteritis / surgery*
  • Time Factors
  • Treatment Outcome
  • Young Adult