Microseiramide from the Freshwater Cyanobacterium Microseira sp. UIC 10445
- PMID: 26089995
- PMCID: PMC4467913
- DOI: 10.1016/j.phytol.2015.05.003
Microseiramide from the Freshwater Cyanobacterium Microseira sp. UIC 10445
Abstract
Microseiramide (1), a cyclic heptapeptide, was isolated from a sample of the freshwater cyanobacterium Microseira sp. UIC 10445 collected in a shallow lake in Northern Indiana. Taxonomic identification of UIC 10445 was performed by a combination of morphological and phylogenetic characterization. Phylogenetic analysis revealed that UIC 10445 was a member of the recently described genus Microseira, which is phylogenetically distinct from the morphologically similar genera. Moorea and Lyngbya. The planar structure of microseiramide (1) was determined by extensive 1D and 2D NMR experiments as well as HRESIMS analysis. The absolute configurations of amino acid residues were determined using acid hydrolysis followed by the advanced Marfey's analysis. microseiramide (1) is the first cyclic peptide reported from a Microseira sp., and the structure of microseiramide (1) is distinct from the previously known metabolites from cyanobacteria of the genera Moorea and Lyngbya.
Keywords: Cyanobacteria; Microseira sp; cyclic hetapeptide; microseiramide.
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