Linking Micronuclei to Chromosome Fragmentation

Cell. 2015 Jun 18;161(7):1502-4. doi: 10.1016/j.cell.2015.06.005.

Abstract

Human cancer cells bear complex chromosome rearrangements that can be potential drivers of cancer development. However, the molecular mechanisms underlying these rearrangements have been unclear. Zhang et al. use a new technique combining live-cell imaging and single-cell sequencing to demonstrate that chromosomes mis-segregated to micronuclei frequently undergo chromothripsis-like rearrangements in the subsequent cell cycle.

Publication types

  • Comment

MeSH terms

  • Chromosome Breakage*
  • DNA Damage*
  • Humans
  • Micronuclei, Chromosome-Defective*