Serum Level of Fibroblast Growth Factor 21 Is Independently Associated with Acute Myocardial Infarction

PLoS One. 2015 Jun 19;10(6):e0129791. doi: 10.1371/journal.pone.0129791. eCollection 2015.


Background: Fibroblast growth factor 21 (FGF21) has been described as a metabolic hormone critical for glucose and lipid metabolism. Previously, high levels of FGF21 were observed in patients with coronary heart disease and non-acute myocardial infarction (non-AMI). In this study, we investigated the changes in FGF21 levels in Chinese patients with AMI.

Methodology/principal findings: We used ELISA to measure circulating FGF21 levels in 55 AMI patients and 45 non-AMI control patients on the 1st day after syndrome onset. All patients were followed-up within 30 days. FGF21 levels in AMI patients were significantly higher than those in non-AMI controls (0.25 (0.16-0.34) vs. 0.14 (0.11-0.20) ng/mL, P < 0.001). FGF21 levels reached the maximum within approximately 24 h after the onset of AMI and remained at high for 7 days, and the FGF21 level (OR: 16.93; 95% confidence interval (CI): 2.65-108.05; P = 0.003) was identified as an independent factor associated with the presence of AMI. On the 7th day, FGF21 levels were significantly higher in the patients who subsequently developed re-infarction within 30 days than in the patients who did not develop re-infarction (with vs. without re-infarction: 0.45 (0.22-0.64) vs. 0.21 (0.15-0.29) ng/mL, P = 0.014).

Conclusions/significance: The level of serum FGF21 is independently associated with the presence of AMI in Chinese patients. High FGF21 levels might be related to the incidence of re-infarction within 30 days after onset.

MeSH terms

  • Aged
  • Biomarkers
  • Case-Control Studies
  • Electrocardiography
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Fibroblast Growth Factors / blood*
  • Humans
  • Male
  • Middle Aged
  • Myocardial Infarction / blood*
  • Myocardial Infarction / diagnosis
  • Myocardial Infarction / etiology
  • Myocardial Infarction / mortality
  • Nutrition Assessment
  • Risk Factors
  • Time Factors


  • Biomarkers
  • fibroblast growth factor 21
  • Fibroblast Growth Factors

Grant support

The authors received no specific funding for this work.