Radiotherapy and immune checkpoint blockade: potential interactions and future directions

Trends Mol Med. 2015 Aug;21(8):463-5. doi: 10.1016/j.molmed.2015.05.007. Epub 2015 Jun 16.

Abstract

Combining radiation and immune checkpoint blockade provides synergistic antitumor responses in animal models and a small subset of patients. New preclinical data have provided mechanistic insight into this treatment interaction and identification of therapeutic targets to optimize this approach.

Keywords: cancer; immunotherapy; radiation.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Animals
  • B7-H1 Antigen / antagonists & inhibitors*
  • CTLA-4 Antigen / antagonists & inhibitors*
  • Cell Cycle Checkpoints / drug effects*
  • Female
  • Humans
  • Melanoma / drug therapy*
  • Melanoma / immunology*
  • Melanoma / radiotherapy*
  • T-Lymphocytes / drug effects*
  • T-Lymphocytes / radiation effects*

Substances

  • B7-H1 Antigen
  • CTLA-4 Antigen