Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Jun 20;14:54.
doi: 10.1186/s12940-015-0042-7.

Parma Consensus Statement on Metabolic Disruptors

Affiliations
Free PMC article

Parma Consensus Statement on Metabolic Disruptors

Jerrold J Heindel et al. Environ Health. .
Free PMC article

Erratum in

  • Correction to: Parma consensus statement on metabolic disruptors.
    Heindel JJ, Vom Saal FS, Blumberg B, Bovolin P, Calamandrei G, Ceresini G, Cohn BA, Fabbri E, Gioiosa L, Kassotis C, Legler J, La Merrill M, Rizzi L, Machtinger R, Mantovani A, Mendez MA, Montanini L, Molteni L, Nagel SC, Parmigiani S, Panzica G, Paterlini S, Pomatto V, Ruzzin J, Sartor G, Schug TT, Street ME, Suvorov A, Volpi R, Zoeller RT, Palanza P. Heindel JJ, et al. Environ Health. 2017 Dec 6;16(1):130. doi: 10.1186/s12940-017-0343-0. Environ Health. 2017. PMID: 29212512 Free PMC article.

Abstract

A multidisciplinary group of experts gathered in Parma Italy for a workshop hosted by the University of Parma, May 16-18, 2014 to address concerns about the potential relationship between environmental metabolic disrupting chemicals, obesity and related metabolic disorders. The objectives of the workshop were to: 1. Review findings related to the role of environmental chemicals, referred to as "metabolic disruptors", in obesity and metabolic syndrome with special attention to recent discoveries from animal model and epidemiology studies; 2. Identify conclusions that could be drawn with confidence from existing animal and human data; 3. Develop predictions based on current data; and 4. Identify critical knowledge gaps and areas of uncertainty. The consensus statements are intended to aid in expanding understanding of the role of metabolic disruptors in the obesity and metabolic disease epidemics, to move the field forward by assessing the current state of the science and to identify research needs on the role of environmental chemical exposures in these diseases. We propose broadening the definition of obesogens to that of metabolic disruptors, to encompass chemicals that play a role in altered susceptibility to obesity, diabetes and related metabolic disorders including metabolic syndrome.

Similar articles

See all similar articles

Cited by 54 articles

  • The EDCMET Project: Metabolic Effects of Endocrine Disruptors.
    Küblbeck J, Vuorio T, Niskanen J, Fortino V, Braeuning A, Abass K, Rautio A, Hakkola J, Honkakoski P, Levonen AL. Küblbeck J, et al. Int J Mol Sci. 2020 Apr 24;21(8):3021. doi: 10.3390/ijms21083021. Int J Mol Sci. 2020. PMID: 32344727 Free PMC article.
  • Endocrine Disrupting Chemicals and Type 1 Diabetes.
    Predieri B, Bruzzi P, Bigi E, Ciancia S, Madeo SF, Lucaccioni L, Iughetti L. Predieri B, et al. Int J Mol Sci. 2020 Apr 22;21(8):2937. doi: 10.3390/ijms21082937. Int J Mol Sci. 2020. PMID: 32331412 Free PMC article. Review.
  • Maternal paraben exposure triggers childhood overweight development.
    Leppert B, Strunz S, Seiwert B, Schlittenbauer L, Schlichting R, Pfeiffer C, Röder S, Bauer M, Borte M, Stangl GI, Schöneberg T, Schulz A, Karkossa I, Rolle-Kampczyk UE, Thürmann L, von Bergen M, Escher BI, Junge KM, Reemtsma T, Lehmann I, Polte T. Leppert B, et al. Nat Commun. 2020 Feb 11;11(1):561. doi: 10.1038/s41467-019-14202-1. Nat Commun. 2020. PMID: 32047148 Free PMC article.
  • In utero DDT exposure and breast density before age 50.
    Krigbaum NY, Cirillo PM, Flom JD, McDonald JA, Terry MB, Cohn BA. Krigbaum NY, et al. Reprod Toxicol. 2019 Nov 8:S0890-6238(19)30094-2. doi: 10.1016/j.reprotox.2019.11.002. Online ahead of print. Reprod Toxicol. 2019. PMID: 31711904
  • Role of Obesogens in the Pathogenesis of Obesity.
    Shahnazaryan U, Wójcik M, Bednarczuk T, Kuryłowicz A. Shahnazaryan U, et al. Medicina (Kaunas). 2019 Aug 21;55(9):515. doi: 10.3390/medicina55090515. Medicina (Kaunas). 2019. PMID: 31438630 Free PMC article. Review.
See all "Cited by" articles

References

    1. O’Neill S, O’Driscoll L. Metabolic syndrome: a closer look at the growing epidemic and its associated pathologies. Obes Rev. 2015;16(1):1–12. doi: 10.1111/obr.12229. - DOI - PubMed
    1. Heindel JJ, vom Saal FS. Role of nutrition and environmental endocrine disrupting chemicals during the perinatal period on the aetiology of obesity. Mol Cell Endocrinol. 2009;304:90–6. doi: 10.1016/j.mce.2009.02.025. - DOI - PubMed
    1. Ogden CL, Carroll MD, Flegal KM. Prevalence of obesity in the United States. JAMA. 2014;312(2):189–90. doi: 10.1001/jama.2014.6228. - DOI - PubMed
    1. Burke JP, Williams K, Gaskill SP, Hazuda HP, Haffner SM, Stern MP. Rapid rise in the incidence of type 2 diabetes from 1987 to 1996: results from the San Antonio Heart Study. Arch Intern Med. 1999;159(13):1450–6. doi: 10.1001/archinte.159.13.1450. - DOI - PubMed
    1. Dabelea D, Mayer-Davis EJ, Saydah S, Imperatore G, Linder B, Divers J, Bell R, Badaru A, Talton JW, Crume T, et al. Prevalence of type 1 and type 2 diabetes among children and adolescents from 2001 to 2009. JAMA. 2014;311(17):1778–86. doi: 10.1001/jama.2014.3201. - DOI - PMC - PubMed

Publication types

MeSH terms

Substances

Feedback