The immune system as a self-centered network of lymphocytes

Immunol Lett. 2015 Aug;166(2):109-16. doi: 10.1016/j.imlet.2015.06.002. Epub 2015 Jun 16.


This essay makes a brief historical and comparative review of selective and network theories of the immune system which is presented as a chemical sensory system with immune and non-immune functions. The ontogeny of immune networks is the result of both positive and negative selection of lymphocytes to self-epitopes that serve as a "template" for the recognition of foreign antigens. The development of immune networks progresses from single individual clones in early ontogeny into complex "information processing networks" in which lymphocytes are linked to inhibitory and stimulatory immune cells. The results of these regulatory interactions modulate immune responses and tolerance.

Keywords: Autoimmunity; B cells; Immune networks; Immunology; Self-peptides; T cells.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Autoimmunity
  • Clonal Evolution / immunology
  • Clonal Selection, Antigen-Mediated / immunology
  • Epitopes / immunology
  • Humans
  • Immune System / cytology*
  • Immune System / physiology*
  • Immunity
  • Immunomodulation
  • Lymphocytes / physiology*
  • Self Tolerance / immunology


  • Epitopes