Low serum omentin levels in the elderly population with Type 2 diabetes and polyneuropathy

Diabet Med. 2015 Nov;32(11):1479-83. doi: 10.1111/dme.12761. Epub 2015 Jun 11.

Abstract

Aims: To investigate the hypothesis that high serum levels of omentin, an adipokine with anti-inflammatory, insulin-sensitizing and cardioprotective properties, may be related to a lower risk of diabetic sensorimotor polyneuropathy.

Methods: The association between serum omentin level and polyneuropathy was estimated in people aged 61-82 years with Type 2 diabetes (47 with and 168 without polyneuropathy) from the population-based KORA F4 study. The presence of clinical diabetic sensorimotor polyneuropathy was defined as bilateral impairment of foot vibration perception and/or foot pressure sensation. Omentin levels were determined by enzyme-linked immunosorbent assay.

Results: Serum omentin level was inversely associated with polyneuropathy after adjustment for age, sex, height, waist circumference, hypertension, total cholesterol, smoking, alcohol intake and physical activity [odds ratio 0.45 (95% CI 0.21-0.98); P = 0.043]. Although omentin was positively correlated with adiponectin (r = 0.55, P < 0.0001) and inversely with tumour necrosis factor-α (r = -0.30, P = 0.019), additional adjustment for adiponectin and tumour necrosis factor-α had little impact on the association.

Conclusions: Serum levels of omentin are reduced in people with Type 2 diabetes and diabetic sensorimotor polyneuropathy, independently of established risk factors of polyneuropathy. This association is only partially explained by biomarkers of subclinical inflammation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adiponectin / blood
  • Aged
  • Aged, 80 and over
  • Aging*
  • Biomarkers / blood
  • Cohort Studies
  • Cross-Sectional Studies
  • Cytokines / blood*
  • Diabetes Mellitus, Type 2 / complications*
  • Diabetic Neuropathies / blood*
  • Diabetic Neuropathies / epidemiology
  • Down-Regulation*
  • Female
  • Follow-Up Studies
  • GPI-Linked Proteins / blood
  • Germany / epidemiology
  • Health Surveys
  • Humans
  • Lectins / blood*
  • Male
  • Polyneuropathies / blood*
  • Polyneuropathies / complications
  • Polyneuropathies / epidemiology
  • Risk Factors
  • Tumor Necrosis Factor-alpha / blood

Substances

  • ADIPOQ protein, human
  • Adiponectin
  • Biomarkers
  • Cytokines
  • GPI-Linked Proteins
  • ITLN1 protein, human
  • Lectins
  • TNF protein, human
  • Tumor Necrosis Factor-alpha