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. 2016;18(1):46-50.
doi: 10.1080/10286020.2015.1055256. Epub 2015 Jun 22.

Two new sesquiterpenoids from cultures of the basidiomycete Tremella foliacea

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Two new sesquiterpenoids from cultures of the basidiomycete Tremella foliacea

Jian-Hai Ding et al. J Asian Nat Prod Res. 2016.

Abstract

Two new sesquiterpenoids, trefoliol B (1) and trefoliol C (2), together with known echinocidin A (3), were isolated from cultures of the basidiomycetes Tremella foliacea. The new structures were elucidated on the basis of extensive spectroscopic methods. At the same time, trefoliol B (1) and echinocidin A (3) were tested for their cytotoxicities against five human cancer cell lines and for their inhibitory activities against isozymes of 11β-hydroxysteroid dehydrogenases (11β-HSD). No compound showed significant activity (IC50 > 40 μM). Compound 1 showed moderate inhibitory activities against 11β-HSD1 (human IC50 = 13.1 μM; mouse IC50 = 91.8 μM).

Keywords: 11β-HSD; Tremella foliacea; cytotoxicities; trefoliols B and C.

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