Effects of blood-flow-restricted resistance training on muscle function in a 74-year-old male with sporadic inclusion body myositis: a case report

Clin Physiol Funct Imaging. 2016 Nov;36(6):504-509. doi: 10.1111/cpf.12259. Epub 2015 Jun 19.


Sporadic inclusion body myositis (sIBM) is a systemic disease that is characterized by substantial skeletal muscle weakness and muscle inflammation, leading to impaired physical function. The objective was to investigate the effect of low-load resistance exercise with concurrent partial blood flow restriction to the working muscles (blood-flow-restricted (BFR) training) in a patient with sIBM. The training consisted of 12 weeks of lower extremity BFR training with low training loads (~25-RM). The patient was tested for mechanical muscle function and functional capacity before and after 6 and 12 weeks of training. Maximal horizontal gait speed increased by 19%, which was accompanied by 38-92% improvements in mechanical muscle function (maximal isometric strength, rate of force development and muscle power). In conclusion, BFR training was well tolerated by the patient with sIBM and led to substantial improvements in mechanical muscle function and gait speed.

Keywords: blood-flow-restricted training; functional capacity; inflammatory myopathy; muscle power; muscle strength; rate of force development.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Biomechanical Phenomena
  • Exercise Test
  • Gait
  • Humans
  • Male
  • Muscle Contraction*
  • Muscle Strength
  • Muscle, Skeletal / blood supply*
  • Myositis, Inclusion Body / diagnosis
  • Myositis, Inclusion Body / physiopathology
  • Myositis, Inclusion Body / therapy*
  • Recovery of Function
  • Regional Blood Flow
  • Resistance Training / methods*
  • Time Factors
  • Tourniquets
  • Treatment Outcome