Hepatitis C virus drug resistance-associated substitutions: State of the art summary

Hepatology. 2015 Nov;62(5):1623-32. doi: 10.1002/hep.27934. Epub 2015 Jul 30.


Hepatitis C virus (HCV) drug development has resulted in treatment regimens composed of interferon-free, all-oral combinations of direct-acting antivirals. While the new regimens are potent and highly efficacious, the full clinical impact of HCV drug resistance, its implications for retreatment, and the potential role of baseline resistance testing remain critical research and clinical questions. In this report, we discuss the viral proteins targeted by HCV direct-acting antivirals and summarize clinically relevant resistance data for compounds that have been approved or are currently in phase 3 clinical trials.

Conclusion: This report provides a comprehensive, systematic review of all resistance information available from sponsors' trials as a tool to inform the HCV drug development field.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review
  • Systematic Review

MeSH terms

  • Antiviral Agents / pharmacology*
  • Drug Discovery*
  • Drug Resistance, Viral
  • Hepacivirus / drug effects*
  • Viral Nonstructural Proteins / antagonists & inhibitors


  • Antiviral Agents
  • NS3 protein, hepatitis C virus
  • NS4B protein, flavivirus
  • Viral Nonstructural Proteins