Resveratrol, in its natural combination in whole grape, for health promotion and disease management

Ann N Y Acad Sci. 2015 Aug;1348(1):150-60. doi: 10.1111/nyas.12798. Epub 2015 Jun 22.


The grape antioxidant resveratrol has been a topic of intense research for the past three decades. Resveratrol and other grape ingredients, as well as whole-grape products, have shown considerable promise in health promotion and disease management. Phytochemically, whole grape represents a natural combination of resveratrol and other phytonutrients, as it contains several catechins, anthocyanins, polyphenols, and flavonols. Thus, whole grape products or specific combinations of grape constituents provide us with the possibility of synergistic interactions leading to improved efficacy. Recent research has suggested that whole-grape products may help in maintaining heart health and protect against aging, aging-associated diseases, neurodegeneration, and some cancers. On the basis of available recent literature, the grape fruit or whole-grape products seem to be safer choices for better health and disease prevention. However, for advanced disease conditions, individual grape ingredients (such as resveratrol) or combinations of multiple ingredients, together with existing therapies, appear to be better approaches. Further clinical studies are needed to understand the benefits of grapes and their products in the prevention and management of specific diseases.

Keywords: clinical trials; grape; resveratrol.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Cardiovascular Diseases / diet therapy
  • Clinical Trials as Topic
  • Diet
  • Disease Management
  • Fruit*
  • Humans
  • Metabolic Diseases / diet therapy
  • Resveratrol
  • Stilbenes / administration & dosage*
  • Vitis*


  • Stilbenes
  • Resveratrol