Comparison of microporous polysaccharide hemospheres and Ankaferd Blood Stopper in a rabbit epistaxis model

Eur Arch Otorhinolaryngol. 2016 Apr;273(4):933-8. doi: 10.1007/s00405-015-3692-8. Epub 2015 Jun 23.


The aim of this study was to evaluate the histopathological impact, effectiveness, and safety of two hemostatic agents, Ankaferd Blood Stopper (ABS) and microporous polysaccharide hemospheres (MPH), in an experimental rabbit epistaxis model. Rabbits were randomly assigned, using a computerized random number generator, to the following three groups of six animals: group 1 (control, irrigated with saline); group 2 (ABS-treated); and group 3 (MPH-treated). In all groups, a standardized rabbit epistaxis model was used. Hemostasis time and extent of nasal bleeding were measured to compare the hemostatic effect of ABS and MPH among groups. Septums were removed for histopathological analysis, 7 days after the procedure. ABS reduced hemostasis time to 104.2 s and amount of bleeding to 20.5 mg. MPH reduced hemostasis time to 71.7 s and amount of bleeding to 11.5 mg. Mean bleeding time in wounds administered ABS and MPH was significantly shorter compared with wounds administered isotonic saline solution (p = 0.004). ABS and MPH application decreased bleeding significantly compared with the control group (p = 0.004). Bleeding time and amount in the MPH group was significantly reduced compared with the ABS group (p = 0.013 and p = 0.004, respectively). There was no significant difference in the histopathological evaluation results between the ABS, MPH, and control groups. Our data indicate that both ABS and MPH represent safe, effective, and fast-acting hemostatic agents in the management of epistaxis. MPH was more effective than ABS in terms of hemostasis time and amount of bleeding.

Keywords: Ankaferd Blood Stopper; Epistaxis treatment; Histopathology; Microporous polysaccharide hemospheres.

MeSH terms

  • Administration, Topical
  • Animals
  • Bleeding Time / methods
  • Disease Models, Animal
  • Epistaxis* / diagnosis
  • Epistaxis* / drug therapy
  • Hemostatics / pharmacology
  • Plant Extracts / pharmacology*
  • Polysaccharides / pharmacology*
  • Rabbits
  • Treatment Outcome


  • Hemostatics
  • Plant Extracts
  • Polysaccharides
  • ankaferd blood stopper