Serum Ischemia-Modified Albumin Levels in Experimental Model of Acute Pancreatitis

J Coll Physicians Surg Pak. 2015 Jun;25(6):395-8.

Abstract

Objective: To establish whether the Ischemia-Modified Albumin (IMA), a new parameter of oxidative stress, has diagnostic role in experimental acute pancreatitis.

Study design: Randomized controlled trial.

Place and duration of study: Experimental Animal Center, Çanakkale Onsekiz Mart University, Çanakkale, Turkey, from May to September 2013.

Methodology: Sixteen Sprague-Dawley rats were randomly divided into two groups (n=8 each): Sham and AP groups. AP was induced by ligation of pancreatic duct. Serum IMA, amylase, lipase, AST, ALT and CRP were determined. The severity of pancreatitis was scored by a blinded pathologist under microscope.

Results: Serum IMA levels in the AP group increased significantly compared with the control group (p < 0.05). There was also a strong positive correlation between amylase and IMA levels.

Conclusion: The present study showed in a rodent model that serum IMA might serve as an additional marker to monitor inflammation during pancreatitis.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Amylases / blood
  • Animals
  • Biomarkers / blood
  • C-Reactive Protein / analysis
  • Humans
  • Ischemia / pathology
  • Ischemia / physiopathology*
  • Male
  • Oxidative Stress / physiology*
  • Pancreatic Ducts
  • Pancreatitis / blood*
  • Pancreatitis / diagnosis
  • Pancreatitis / pathology
  • Rats
  • Rats, Sprague-Dawley
  • Serum Albumin
  • Serum Albumin, Human

Substances

  • Biomarkers
  • Serum Albumin
  • ischemia-modified albumin
  • C-Reactive Protein
  • Amylases
  • Serum Albumin, Human