FGDF motif regulation of stress granule formation

DNA Cell Biol. 2015 Sep;34(9):557-60. doi: 10.1089/dna.2015.2957. Epub 2015 Jun 23.


RNA stress granules (SGs) represent a cell-intrinsic antiviral defense mechanism. The assembly of SGs in response to viral infection is coordinated by the cellular protein G3BP, which is targeted by many viruses to block SG formation. We recently showed that proteins containing the short linear motif Phe-Gly-Asp-Phe (FGDF), bind G3BP in a hydrophobic groove on the surface of the nuclear transport factor-2-like domain. Binding in this manner blocks the ability of G3BP to form SGs and allows efficient replication of viruses carrying this motif.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adaptor Proteins, Signal Transducing / metabolism
  • Amino Acid Motifs
  • Animals
  • Binding Sites
  • Cytoplasmic Granules / physiology*
  • Humans
  • Hydrophobic and Hydrophilic Interactions
  • Protein Binding


  • Adaptor Proteins, Signal Transducing