Solanum tuberosum L. cv Jayoung Epidermis Extract Inhibits Mite Antigen-Induced Atopic Dermatitis in NC/Nga Mice by Regulating the Th1/Th2 Balance and Expression of Filaggrin

J Med Food. 2015 Sep;18(9):1013-21. doi: 10.1089/jmf.2014.3338. Epub 2015 Jun 23.

Abstract

Solanum tuberosum L. cv Jayoung (JY) is a potato with dark purple flesh and contains substantial amounts of polyphenols. In this study, we evaluated the therapeutic effects of S. tuberosum L. cv JY in a mouse model of Dermatophagoides farinae body (Dfb)-induced atopic dermatitis (AD). The ethanol extract of the peel of JY (EPJ) ameliorated Dfb-induced dermatitis severity, serum levels of immunoglobulin E (IgE) and thymus and activation-regulated chemokine. Histological analysis of the skin also revealed that EPJ treatment significantly decreased mast cell infiltration. The suppression of dermatitis by EPJ treatment was accompanied by a decrease in the skin levels of type 2 helper T-cell cytokines such as interleukin (IL)-4, IL-5, and IL-13. The induction of thymic stromal lymphopoietin, which leads to a systemic Th2 response, was also decreased in the skin by EPJ. Nuclear translocation of nuclear factor-κB p65 was decreased by EPJ in Dfb-induced NC/Nga mice. The protein expression of filaggrin in the AD-like skin lesions was restored by EPJ treatment. These results suggested that EPJ may be a potential therapeutic tool for the treatment of AD.

Keywords: IgE; NF-κB; Solanum tuberosum L. cv Jayoung; Th2; atopic dermatitis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antigens
  • Cytokines / blood
  • Dermatitis, Atopic / drug therapy*
  • Dermatitis, Atopic / etiology
  • Dermatitis, Atopic / immunology
  • Dermatitis, Atopic / metabolism
  • Filaggrin Proteins
  • Intermediate Filament Proteins / metabolism
  • Male
  • Mice
  • Mites*
  • Phytotherapy*
  • Plant Epidermis
  • Plant Extracts / pharmacology
  • Plant Extracts / therapeutic use*
  • Polyphenols / pharmacology
  • Polyphenols / therapeutic use
  • Skin / drug effects*
  • Skin / metabolism
  • Skin / pathology
  • Solanum tuberosum / chemistry*
  • T-Lymphocytes, Helper-Inducer / metabolism
  • Th1 Cells / metabolism
  • Th1-Th2 Balance / drug effects*
  • Th2 Cells / metabolism

Substances

  • Antigens
  • Cytokines
  • Filaggrin Proteins
  • Intermediate Filament Proteins
  • Plant Extracts
  • Polyphenols