Skeletal muscle-resident MSCs and bone formation

Bone. 2015 Nov:80:19-23. doi: 10.1016/j.bone.2015.06.013. Epub 2015 Jun 21.


Recent research has highlighted the importance of bone and muscle interactions during development and regeneration. There still remains, however, a large gap in the current understanding of the cells and mechanisms involved in this interplay. In particular, how muscle-derived cells, specifically mesenchymal stromal cells (MSCs), can impact bone regeneration or lead to pathologic ectopic bone formation is unclear. Here, a review is given of the evidence supporting the contribution of muscle-derived MSC to bone regeneration and suggesting a critical role for the inflammatory milieu. This article is part of a Special Issue entitled "Muscle Bone Interactions".

Keywords: Bone formation; Fracture repair; MSC; Skeletal muscle.

Publication types

  • Review

MeSH terms

  • Animals
  • Bone Regeneration / physiology
  • Fractures, Bone
  • Humans
  • Mesenchymal Stem Cell Transplantation
  • Mesenchymal Stem Cells / cytology*
  • Mesenchymal Stem Cells / physiology
  • Muscle, Skeletal / cytology*
  • Muscle, Skeletal / physiology*
  • Osteogenesis / physiology*