Molecular Basis of Drug Resistance in Mycobacterium tuberculosis

Microbiol Spectr. 2014 Jun;2(3). doi: 10.1128/microbiolspec.MGM2-0036-2013.


In this chapter we review the molecular mechanisms of drug resistance to the major first- and second-line antibiotics used to treat tuberculosis.

Publication types

  • Review

MeSH terms

  • Antitubercular Agents / pharmacology*
  • Drug Resistance, Bacterial*
  • Gene Expression Regulation
  • Genes, Bacterial*
  • Mutation, Missense
  • Mycobacterium tuberculosis / drug effects*
  • Mycobacterium tuberculosis / genetics*


  • Antitubercular Agents