Genetic and preeclampsia

Pregnancy Hypertens. 2014 Jul;4(3):243. doi: 10.1016/j.preghy.2014.04.012. Epub 2014 Jul 9.


Preeclampsia is usually called as a disease of theories where the real etipatology still unclear. Preeclampsia is a medical complication of pregnancy which is characterized by hypertension and proteinuria after 20week pregnancy. It is kown that preeclampsia has a clear genetic component. Polymorphism of the KIR genes might be associated with the genetic predisposition of preeclampsia. It is found that the KIR3DL2 (Killer cell immunoglobuline-like receptor 3 domains, long cytoplasmic tail, 2 (KIR3DL2) gene expression was obviously decreased in preeclampsia and assumed that decreased KIR3DL2 gene expression weakened the protection of trophoblasts from being attacked by maternal immunological cell and made in adequate trophoblast invasion in early pregnancy. It causes insufficient utero-placental blood flow and the defective piacentation.