Effect of Serenoa Repens on Oxidative Stress, Inflammatory and Growth Factors in Obese Wistar Rats with Benign Prostatic Hyperplasia

Phytother Res. 2015 Oct;29(10):1525-31. doi: 10.1002/ptr.5406. Epub 2015 Jun 24.


Serenoa repens has been widely used to treat benign prostatic hyperplasia and lower urinary tract symptoms; however, most of the studies have been conducted in individuals with normal weight and not obese. In this study, the effects of a lipidic extract of S. repens, in markers of oxidative stress, inflammation, and growth factors, in obese rats with testosterone-induced prostatic hyperplasia, were investigated. Total nitrites, malondialdehyde, total glutathione, superoxide dismutase (SOD), and catalase activity were measured; in addition, assays for inflammatory cytokines TNF-α, IL-1β, IL-6 and the growth factors basic fibroblast growth factor (FGFb) and vascular endothelial growth factor (VEGF) were performed. The obese rats had a higher prostate weight compared with controls. S. repens significantly decreased prostate weight, total nitrites, and malondialdehyde; improved total glutathione, SOD, and catalase activity; and significantly reduced inflammatory (TNF-α, IL-1β and IL-6) and growth factors (VEGF and FGFb). S. repens showed high antioxidant and antiinflammatory activity in obese rats, suggesting that their use could be beneficial in the treatment of benign prostatic hyperplasia.

Keywords: Serenoa repens; growth factors; obesity; oxidative stress; prostatic hyperplasia; testosterone.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Androgen Antagonists / therapeutic use
  • Animals
  • Anti-Inflammatory Agents / therapeutic use
  • Antioxidants / therapeutic use
  • Humans
  • Inflammation / drug therapy
  • Interleukin-6
  • Male
  • Obesity / complications
  • Obesity / drug therapy*
  • Oxidative Stress
  • Phytotherapy
  • Plant Extracts
  • Prostatic Hyperplasia / complications
  • Prostatic Hyperplasia / drug therapy*
  • Rats
  • Rats, Wistar
  • Serenoa
  • Tumor Necrosis Factor-alpha
  • Vascular Endothelial Growth Factor A


  • Androgen Antagonists
  • Anti-Inflammatory Agents
  • Antioxidants
  • Interleukin-6
  • Plant Extracts
  • TNF protein, human
  • Tumor Necrosis Factor-alpha
  • Vascular Endothelial Growth Factor A
  • saw palmetto extract