Objectives: To examine the cross-sectional associations between serum magnesium (Mg) and hyperuricemia (HU).
Methods: 2904 subjects were included in this study. HU was defined as uric acid ≥416 μmol/L for the male population and ≥360 μmol/L for the female population. A multivariable logistic analysis model was applied to test the associations after adjusting for a number of potential confounding factors.
Results: The relative odds of the prevalence of HU were significantly decreased by 0.65 times in the third quintile of serum Mg (OR 0.65, 95% CI 0.47-0.89), and 0.61 times in the fifth quintile (OR 0.61, 95% CI 0.45-0.83), compared with the lowest quintile: P for trend was 0.002. For males, the relative odds for HU were significantly decreased by 0.61 times in the third quintile of serum Mg (OR 0.61, 95% CI 0.42-0.89), 0.68 times in the fourth quintile (OR 0.68, 95% CI 0.47-0.97), and 0.59 times in the fifth quintile (OR 0.59, 95% CI 0.41-0.84) compared with the lowest quintile: P for trend was 0.003. However, no significant association was observed between serum Mg and HU for females.
Conclusion: Serum Mg is inversely associated with HU. This association remains valid for the male subgroup, but not for the female subgroup.