Abstract
An esterification/Friedel-Crafts-cyclization approach permitted the first successful synthetic entry into the oxacyclododecindione subclass of the dihydroxyphenylacetic acid lactone-type natural products. This route allowed the preparation of two highly active anti-inflammatory fungal secondary metabolites 14-deoxyoxacyclododecindione and 14-deoxy-4-dechlorooxacyclododecindione as well as their 14-desmethyl analogues.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis*
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Anti-Inflammatory Agents, Non-Steroidal / chemistry
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Cyclization
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Lactones / chemical synthesis*
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Lactones / chemistry
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Macrocyclic Compounds / chemical synthesis*
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Macrocyclic Compounds / chemistry
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Molecular Structure
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Lactones
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Macrocyclic Compounds
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oxacyclododecindione