One year in review 2015: systemic lupus erythematosus

Clin Exp Rheumatol. May-Jun 2015;33(3):414-25. Epub 2015 Jun 22.


Systemic lupus erythematosus is a multiorgan autoimmune disease with a highly variable clinical course, typically involving women in childbearing age. At present, many aspects of its pathogenesis still remain unclear. Moreover, although a significant increase of patient survival has been observed in the last decades, morbidity and mortality remain high. Finally, SLE impacts negatively on the health-related quality-of-life of patients. Therefore, multiple aspects of SLE still remain challenging and it continues to be the object of both clinical and translational clinical research. Herewith, we provide a critical digest of the recent literature on this topic.

Publication types

  • Review

MeSH terms

  • Animals
  • Cost of Illness
  • Disease Progression
  • Humans
  • Immunosuppressive Agents / therapeutic use
  • Lupus Erythematosus, Systemic* / diagnosis
  • Lupus Erythematosus, Systemic* / drug therapy
  • Lupus Erythematosus, Systemic* / etiology
  • Lupus Erythematosus, Systemic* / mortality
  • Predictive Value of Tests
  • Quality of Life
  • Risk Factors
  • Severity of Illness Index
  • Time Factors
  • Treatment Outcome


  • Immunosuppressive Agents