Metabolic syndrome resolution by Roux-en-Y gastric bypass in a real world: a case control study

Rev Assoc Med Bras (1992). Mar-Apr 2015;61(2):161-9. doi: 10.1590/1806-9282.61.02.161.


Objectives: the aim of this study was to evaluate the efficacy of Roux-en-Y Gastric Bypass (RYGB), compared with nonsurgical treatment (NS group), as an instrument for inducing remission of co-morbidities related to Metabolic Syndrome (MetS) in patients with Obesity, grades 2 and 3 (Ob2,3).

Methods: two hundred and fifty eight Ob2,3 patients were selected in a retrospective analysis and included in a case control study. MetS was defined as described by the International Diabetes Federation. One hundred and twenty-nine of these patients underwent RYGB (S group), and 129 were assessed as an NS group.

Results: at baseline, S and NS groups did not differ in BMI, age, female sex and prevalence of MetS (p>0.05). For the S group the outcomes were a reduction in BMI of 38.1% (p<0.001), waist circumference of 28.6% (p<0.001), fasting plasma glucose of 10.5% (p<0.001), serum LDL-cholesterol of 21.9% (p<0.001) and of 85% in the number of patients with MetS (p<0.001). For the NS group, only a decrease of 4.12%(p=0.047) in triglyceride levels and of 5.9%(p=0.031) in Diastolic Blood Pressure was observed. In the NS group, 98.6% of the patients continued to have MetS. The number needed to treat (NNT) with surgery to resolve one case of MetS was 1.2 (CI 95%: 1.1 - 1.4).

Conclusion: in the real world, in the South of Brazil, compared with NS treatment and after 1 year of observation, RYGB is highly effective for decreasing the prevalence of MetS.

MeSH terms

  • Adult
  • Body Mass Index
  • Brazil
  • Case-Control Studies
  • Cohort Studies
  • Female
  • Gastric Bypass / methods*
  • Humans
  • Metabolic Syndrome / therapy*
  • Obesity / metabolism
  • Obesity, Morbid / therapy*
  • Retrospective Studies
  • Treatment Outcome
  • Waist Circumference
  • Weight Loss