Rh(III)-Catalyzed C-H Amidation of Indoles with Isocyanates

J Org Chem. 2015 Jul 17;80(14):7243-50. doi: 10.1021/acs.joc.5b00763. Epub 2015 Jul 1.

Abstract

The rhodium(III)-catalyzed direct amidation of indoles and pyrroles with aryl and alkyl isocyanates is described. These transformations provide a facile and efficient construction of C2-amidated N-heterocyclic scaffolds.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amides / chemistry*
  • Catalysis
  • Heterocyclic Compounds / chemical synthesis*
  • Heterocyclic Compounds / chemistry
  • Indoles / chemistry*
  • Isocyanates / chemistry*
  • Molecular Structure
  • Pyrroles / chemistry*
  • Rhodium / chemistry

Substances

  • Amides
  • Heterocyclic Compounds
  • Indoles
  • Isocyanates
  • Pyrroles
  • Rhodium