Lucilia cuprina genome unlocks parasitic fly biology to underpin future interventions

Nat Commun. 2015 Jun 25:6:7344. doi: 10.1038/ncomms8344.


Lucilia cuprina is a parasitic fly of major economic importance worldwide. Larvae of this fly invade their animal host, feed on tissues and excretions and progressively cause severe skin disease (myiasis). Here we report the sequence and annotation of the 458-megabase draft genome of Lucilia cuprina. Analyses of this genome and the 14,544 predicted protein-encoding genes provide unique insights into the fly's molecular biology, interactions with the host animal and insecticide resistance. These insights have broad implications for designing new methods for the prevention and control of myiasis.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Diptera / genetics*
  • Female
  • Gene Expression Regulation / physiology*
  • Genome, Insect*
  • Insect Proteins / genetics
  • Insect Proteins / metabolism*
  • Insecticide Resistance / genetics
  • Insecticides / pharmacology
  • Larva
  • Male
  • Transcriptome


  • Insect Proteins
  • Insecticides