MicroRNA-551b is highly expressed in hematopoietic stem cells and a biomarker for relapse and poor prognosis in acute myeloid leukemia

Leukemia. 2016 Mar;30(3):742-6. doi: 10.1038/leu.2015.160. Epub 2015 Jun 25.

Authors

D C de Leeuw¹, H J M P Verhagen¹, F Denkers¹, F G Kavelaars², P J M Valk², G J Schuurhuis¹, G J Ossenkoppele¹, L Smit¹

Affiliations

¹ Department of Hematology, VU University Medical Center, Cancer Center Amsterdam, Amsterdam, The Netherlands.
² Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands.

PMID: 26108690
DOI: 10.1038/leu.2015.160

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Aged
Antineoplastic Agents / therapeutic use
Biomarkers, Tumor / genetics*
Biomarkers, Tumor / metabolism
Epigenesis, Genetic*
Female
Hematopoiesis / genetics
Hematopoietic Stem Cells
Humans
Leukemia, Myeloid, Acute / diagnosis*
Leukemia, Myeloid, Acute / drug therapy
Leukemia, Myeloid, Acute / genetics*
Leukemia, Myeloid, Acute / mortality
Male
MicroRNAs / genetics*
MicroRNAs / metabolism
Middle Aged
Neoplasm, Residual
Prognosis
Recurrence
Remission Induction
Survival Analysis

Substances

Antineoplastic Agents
Biomarkers, Tumor
MIRN-551 microRNA, human
MicroRNAs