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. 2015 Jun 24;107(8):djv153.
doi: 10.1093/jnci/djv153. Print 2015 Aug.

Sensitivity, Specificity, PPV, and NPV for Predictive Biomarkers

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Free PMC article

Sensitivity, Specificity, PPV, and NPV for Predictive Biomarkers

Richard Simon. J Natl Cancer Inst. .
Free PMC article

Abstract

Molecularly targeted cancer drugs are often developed with companion diagnostics that attempt to identify which patients will have better outcome on the new drug than the control regimen. Such predictive biomarkers are playing an increasingly important role in precision oncology. For diagnostic tests, sensitivity, specificity, positive predictive value, and negative predictive are usually used as performance measures. This paper discusses these indices for predictive biomarkers, provides methods for their calculation with survival or response endpoints, and describes assumptions involved in their use.

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