Inflammatory and Other Biomarkers: Role in Pathophysiology and Prediction of Gestational Diabetes Mellitus

Int J Mol Sci. 2015 Jun 11;16(6):13442-73. doi: 10.3390/ijms160613442.


Understanding pathophysiology and identifying mothers at risk of major pregnancy complications is vital to effective prevention and optimal management. However, in current antenatal care, understanding of pathophysiology of complications is limited. In gestational diabetes mellitus (GDM), risk prediction is mostly based on maternal history and clinical risk factors and may not optimally identify high risk pregnancies. Hence, universal screening is widely recommended. Here, we will explore the literature on GDM and biomarkers including inflammatory markers, adipokines, endothelial function and lipids to advance understanding of pathophysiology and explore risk prediction, with a goal to guide prevention and treatment of GDM.

Keywords: biomarkers; gestational diabetes mellitus; inflammatory markers; pregnancy; risk prediction.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Biomarkers / metabolism*
  • Diabetes, Gestational / diagnosis*
  • Diabetes, Gestational / metabolism
  • Diabetes, Gestational / physiopathology*
  • Female
  • Humans
  • Inflammation Mediators / metabolism*
  • Pregnancy


  • Biomarkers
  • Inflammation Mediators