Non-enzymatic cyclic oxygenated metabolites of omega-3 polyunsaturated fatty acid: Bioactive drugs?

Biochimie. 2016 Jan;120:56-61. doi: 10.1016/j.biochi.2015.06.010. Epub 2015 Jun 23.


Non-enzymatic oxygenated metabolites derived from polyunsaturated fatty acids (PUFA) are formed in vivo through free radical reaction under oxidative stress conditions. It has been over twenty-five years since the discovery of cyclic oxygenated metabolites derived from arachidonic acid (20:4 n-6), the isoprostanes, and since then they have become biomarkers of choice for assessing in vivo OS in humans and animals. Chemical synthesis of n-3 PUFA isoprostanoids such as F3-Isoprostanes from eicosapentaenoic acid (20:5 n-3), and F4-Neuroprostanes from docosahexaenoic acid (22:6 n-6) unravelled novel and unexpected biological properties of such omega-3 non-enzymatic cyclic metabolites as highlighted in this review.

Keywords: Arrhythmia; Isoprostanes; Neuroprostanes; Omega-3 PUFA; Oxidative stress.

Publication types

  • Review

MeSH terms

  • Animals
  • Arachidonic Acid / metabolism*
  • Eicosapentaenoic Acid / metabolism*
  • Humans
  • Isoprostanes / metabolism*
  • Oxidation-Reduction
  • Oxidative Stress*


  • Isoprostanes
  • Arachidonic Acid
  • Eicosapentaenoic Acid