Interaction between Common Genetic Variants and Total Fat Intake on Low-Density Lipoprotein Peak Particle Diameter: A Genome-Wide Association Study

J Nutrigenet Nutrigenomics. 2015;8(1):44-53. doi: 10.1159/000431151. Epub 2015 Jun 20.


Background/aim: Total fat intake has an important impact on the low-density lipoprotein (LDL) peak particle diameter (LDL-PPD) and may interact with nutrient-sensitive single nucleotide polymorphisms (SNPs). The objective was to examine whether there is suggestive evidence of SNP × dietary fat intake interaction effects influencing the LDL-PPD in the Quebec Family Study (QFS) in order to generate hypotheses to be tested in larger studies.

Methods: SNPs from a genome-wide association study (GWAS) using Illumina Human610-Quad BeadChip, total fat intake derived from a 3-day weighted food record, and SNP × total fat intake interaction effects were examined on LDL-PPD in 541 QFS subjects.

Results: The GWAS analyses 29 identified independent SNP × total fat intake interaction effects on the LDL-PPD at p < 10(-5), including SNPs in the following genes: ABCG2, CPA3, FNBP1, KCNQ3, NBAS, NCALD, OPRL1, NKAIN2, SH3BGRL2, SOX5, and SUSD4.

Conclusions: This observational study suggests that multiple SNPs interact with dietary fat intake to influence variation in the LDL-PPD.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Diet Records
  • Dietary Fats / administration & dosage*
  • Female
  • Genome-Wide Association Study*
  • Humans
  • Lipoproteins, LDL / blood*
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide
  • Quebec


  • Dietary Fats
  • Lipoproteins, LDL