TB vaccines; promoting rapid and durable protection in the lung

Curr Opin Immunol. 2015 Aug;35:55-62. doi: 10.1016/j.coi.2015.06.001. Epub 2015 Jun 22.

Abstract

TB vaccine discovery has focused on IFN-γ both for the selection of antigens and vaccine delivery strategies. Recent breakthroughs in our understanding of the requirements for immunological memory and the expression of immunity to TB in the lung now provide a framework for reconsidering that strategy. We will discuss the status of the TB vaccine field, recent insights into the role of central memory cells and the potential of tissue-resident memory cells in vaccine promoted protection against TB.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Clinical Trials as Topic
  • Humans
  • Immunologic Memory
  • Interferon-gamma / metabolism
  • Lung / immunology*
  • Lung / microbiology
  • Mycobacterium tuberculosis / immunology*
  • T-Lymphocytes / immunology*
  • T-Lymphocytes / microbiology
  • T-Lymphocytes / transplantation
  • Tuberculosis / immunology
  • Tuberculosis / prevention & control*
  • Vaccines / immunology*

Substances

  • Vaccines
  • Interferon-gamma