Absorption kinetics of cyclosporine in healthy volunteers

Biopharm Drug Dispos. Nov-Dec 1989;10(6):591-6. doi: 10.1002/bdd.2510100608.

Abstract

The absorption kinetics of cyclosporine were studied in eight healthy volunteers following oral and intravenous administration. Bioavailability of cyclosporine was observed to be 20.8 +/- 5.5 per cent. Absorption of cyclosporine was found to be better described by first order processes rather than by a zero order process as previously reported.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Administration, Oral
  • Biological Availability
  • Cyclosporins / administration & dosage
  • Cyclosporins / pharmacokinetics*
  • Female
  • Humans
  • Infusions, Intravenous
  • Intestinal Absorption
  • Male

Substances

  • Cyclosporins