Peak oxygen uptake, ventilatory efficiency and QRS-duration predict event free survival in patients late after surgical repair of tetralogy of Fallot

Int J Cardiol. 2015 Oct 1:196:158-64. doi: 10.1016/j.ijcard.2015.05.174. Epub 2015 Jun 2.


Objective: Patients with repaired tetralogy of Fallot (ToF) have an increased long-term risk of cardiovascular morbidity and mortality. Risk stratification in this population is difficult. Initial evidence suggests that cardiopulmonary exercise testing (CPET) may be helpful to risk-stratify patients with repaired ToF.

Methods and results: We studied 875 patients after surgical repair for ToF (358 females, age 25.5 ± 11.7 year, range 7-75 years) who underwent CPET between 1999 and 2009. During a mean follow-up of 4.1 ± 2.6 years after CPET, 30 patients (3.4%) died or had sustained ventricular tachycardia (VT). 225 patients (25.7%) had other cardiac related events (emergency admission, surgery, or catheter interventions). On multivariable Cox regression-analysis, %predicted peak oxygen uptake (V˙O2 %) (p=0.001), resting QRS duration (p=0.030) and age (p<0.001) emerged as independent predictors of mortality or sustained VT. Patients with a peak V˙O2 ≤ 65% of predicted and a resting QRS duration ≥ 170 ms had a 11.4-fold risk of death or sustained VT. Ventilatory efficiency expressed as V˙E/V˙CO2 slope (p<0.001), peak V˙O2 % (p=.001), QRS duration (p=.001) and age (p=0.046) independently predicted event free survival. V˙E/V˙CO2 slope ≥ 31.0, peak V˙O2 % ≤ 65% and QRS duration ≥ 170 ms were the cut-off points with best sensitivity and specificity to detect an unfavorable outcome.

Conclusions: CPET is an important predictive tool that may assist in the risk stratification of patients with ToF. Subjects with a poor exercise capacity in addition to a prolonged QRS duration have a substantially increased risk for death or sustained ventricular tachycardia, as well as for cardiac-related hospitalizations.

Keywords: Event free survival; Exercise testing; Peak VO(2); QRS duration; Tetralogy of Fallot; Ventilatory efficiency.

Publication types

  • Multicenter Study

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Child
  • Disease-Free Survival
  • Electrocardiography
  • Exercise Test
  • Exercise Tolerance / physiology
  • Female
  • Humans
  • Male
  • Middle Aged
  • Oxygen Consumption / physiology*
  • Pulmonary Ventilation / physiology*
  • Retrospective Studies
  • Risk Factors
  • Tachycardia, Ventricular / epidemiology
  • Tetralogy of Fallot / mortality
  • Tetralogy of Fallot / physiopathology
  • Tetralogy of Fallot / surgery*
  • Young Adult