Pulsatile release of acetylcholinesterase from the substantia nigra following electrical stimulation of the striatum

Brain Res. 1989 Dec 25;505(1):153-6. doi: 10.1016/0006-8993(89)90128-5.

Abstract

The spatio-temporal characteristics of release of acetylcholinesterase from the in vivo substantia nigra can now be described using a chemiluminescent reaction. Electrical stimulation of the striatum caused an increase in release of acetylcholinesterase within the ipsilateral substantia nigra; however, this increase in release of protein was non-uniform and pulsatile. The findings suggest that release of acetylcholinesterase within the substantia nigra has a fine space-time resolution never before appreciated.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetylcholinesterase / pharmacokinetics*
  • Animals
  • Benzenaminium, 4,4'-(3-oxo-1,5-pentanediyl)bis(N,N-dimethyl-N-2-propenyl-), Dibromide / pharmacology
  • Corpus Striatum / physiology*
  • Electric Stimulation
  • Guinea Pigs
  • Male
  • Neural Pathways
  • Substantia Nigra / metabolism*

Substances

  • Benzenaminium, 4,4'-(3-oxo-1,5-pentanediyl)bis(N,N-dimethyl-N-2-propenyl-), Dibromide
  • Acetylcholinesterase