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. 2015 Sep;64(9):991-8.
doi: 10.1016/j.metabol.2015.06.002. Epub 2015 Jun 6.

In Adult Twins, Visceral Fat Accumulation Depends More on Exceeding Sex-Specific Adiposity Thresholds Than on Genetics

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Free PMC article

In Adult Twins, Visceral Fat Accumulation Depends More on Exceeding Sex-Specific Adiposity Thresholds Than on Genetics

Tyler A Bosch et al. Metabolism. .
Free PMC article

Abstract

Objective: We recently reported sex-specific percent body fat (%BF) thresholds (males=23%, females=38%) above which, visceral adipose tissue (VAT) significantly increases. Using monozygotic (MZ) and dizygotic (DZ) twins, we examined the influence of genetics on regional fat distribution measured by dual-energy X-ray absorptiometry, above and below these sex-specific thresholds for VAT accumulation.

Methods: Fifty-eight twin pairs (44 MZ, 14 DZ) were recruited from the University of Washington Twin Registry. Segmented linear regression was used to assess the threshold between VAT mass and %BF by sex and by zygosity. To assess the effect of genetics on VAT accumulation, Dunnett's T3 compared MZ and DZ pairs whether the twin pairs were both above the adiposity threshold or not.

Results: %BF thresholds for VAT accumulation were identified (%BF: M=20.6%, F=39.4%). Zygosity-specific thresholds were not significantly different (p>0.05). If at least one twin was below threshold, DZ twins still exhibited greater within-pair differences than MZ pairs in %BF (p=0.023) but not VAT (p=0.121).

Conclusions: Using a twin study approach, we observed no difference by zygosity for the threshold as which VAT accumulates. Additionally, for the first time we observed that while total BF is influenced by genetics, VAT accumulation may depend more on whether a person's %BF is above their sex-specific adiposity threshold. These results suggest that there may not be a genetic predisposition for VAT accumulation but rather it is a result of a predisposition for total fat accumulation.

Keywords: DXA; Ectopic fat; Fat distribution; Zygosity.

Figures

Figure 1
Figure 1
Sex-specific percent body fat thresholds for males (open triangles) and females (open circles) for VAT mass.
Figure 2
Figure 2
Zygosity-specific thresholds for VAT mass based on the difference from the sex-specific adiposity thresholds, MZ (open triangles), DZ (open circles).

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