The results of systemic immunological reactivity research were presented in 97 patients with chronic obstructive pulmonary disease (COPD) exacerbations. The patients were randomized on two groups. 67 patients, which additionally to standard anti-inflammatory therapy were prescribed different combinations of homotoxicological medicines, entered in a clinical group. The homotoxicological medicines such as Lymphomyosot, Galium-Heel®, Traumeel S, Echinacea compositum S, Bronchalis-Heel®, Mucosa compositum were prescribed according to the value of immune-regulatory index and type of T-cells immune disorders. 30 patients, which got standard anti-inflammatory therapy, entered in the group. of comparison. For the patients of clinical group immunological values were improved after the conducted treatment, unlike the patients of group of comparison in which an immunodeficiency was deepened.