NAD(+) Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus

Cell Metab. 2015 Jul 7;22(1):31-53. doi: 10.1016/j.cmet.2015.05.023. Epub 2015 Jun 25.

Abstract

NAD(+) has emerged as a vital cofactor that can rewire metabolism, activate sirtuins, and maintain mitochondrial fitness through mechanisms such as the mitochondrial unfolded protein response. This improved understanding of NAD(+) metabolism revived interest in NAD(+)-boosting strategies to manage a wide spectrum of diseases, ranging from diabetes to cancer. In this review, we summarize how NAD(+) metabolism links energy status with adaptive cellular and organismal responses and how this knowledge can be therapeutically exploited.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Aging
  • Animals
  • Cell Nucleus / metabolism*
  • Energy Metabolism*
  • Homeostasis*
  • Humans
  • Metabolic Diseases / metabolism
  • Mitochondria / metabolism*
  • Molecular Targeted Therapy
  • NAD / metabolism*
  • Neoplasms / metabolism
  • Neurodegenerative Diseases / metabolism
  • Poly(ADP-ribose) Polymerases / metabolism
  • Sirtuins / metabolism

Substances

  • NAD
  • Poly(ADP-ribose) Polymerases
  • Sirtuins