Hyaluronic Acid: Perspectives in Upper Aero-Digestive Tract. A Systematic Review

PLoS One. 2015 Jun 29;10(6):e0130637. doi: 10.1371/journal.pone.0130637. eCollection 2015.


Background: To date, topical therapies guarantee a better delivery of high concentrations of pharmacologic agents to the mucosa of the upper aerodigestive tract (UADT). The use of topical drugs, which are able to reduce mucosal inflammation and to improve healing tissues, can represent a relevant therapeutic advance. Topical sodium hyaluronate (SH) has recently been recognized as adjuvant treatment in the chronic inflammatory disease of the UADT.

Aims: The aim of our work was to review the published literature regarding all the potential therapeutic effects of SH in the chronic inflammatory disease of UADT.

Methods: Relevant published studies were searched in Pubmed, Google Scholar, Ovid using keywords ("sodium hyaluronate" and "upper airways") or Medical Subject Headings.

Results: At the end of our selection process, sixteen publications have been included. Six of them in the post-operative period of nasal-sinus surgery, 2 of them in pediatric patients affected by recurrent upper respiratory tract infections, 4 of them in reducing symptoms and preventing exacerbations of chronic upper airways in adult population, 4 of them in patients with chronic inflammatory disease of UADT, including gastro-esophageal reflux disease (GERD).

Conclusions: Topical administration of SH plays a pivotkey role in the postoperative phase of patients undergoing FESS and nasal surgery, and positive results are generally observed in all the patients suffering from UADT chronic inflammatory disease.

Publication types

  • Meta-Analysis
  • Review
  • Systematic Review

MeSH terms

  • Adult
  • Child
  • Gastrointestinal Tract / drug effects
  • Gastrointestinal Tract / pathology*
  • Humans
  • Hyaluronic Acid / pharmacology*
  • Hyaluronic Acid / therapeutic use
  • Inflammation / drug therapy
  • Inflammation / pathology
  • Mucous Membrane / drug effects
  • Mucous Membrane / pathology
  • Nose / surgery
  • Paranasal Sinuses / drug effects
  • Paranasal Sinuses / surgery
  • Respiratory System / drug effects
  • Respiratory System / pathology*
  • Wound Healing / drug effects


  • Hyaluronic Acid

Grants and funding

The authors have no support or funding to report.