Innate lymphoid cells in the initiation, regulation and resolution of inflammation

Nat Med. 2015 Jul;21(7):698-708. doi: 10.1038/nm.3892. Epub 2015 Jun 29.


A previously unappreciated cell type of the innate immune system, termed innate lymphoid cells (ILCs), has been characterized in mice and humans and found to influence the induction, regulation and resolution of inflammation. ILCs have an important role in these processes in mouse models of infection, inflammation and tissue repair. Further, disease-association studies in defined patient populations have identified significant alterations in ILC responses, suggesting a potential role for these cell populations in human health and disease. In this review we discuss the emerging family of ILCs, the role of ILCs in inflammation, and how current or novel therapeutic strategies could be used to selectively modulate ILC responses and limit chronic inflammatory diseases.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Communicable Diseases / microbiology
  • Communicable Diseases / parasitology
  • Humans
  • Immunity, Innate*
  • Inflammation / immunology*
  • Inflammation / pathology*
  • Lymphocytes / immunology*
  • Models, Immunological
  • Wound Healing