How cells coordinate waste removal through their major proteolytic pathways

Nat Cell Biol. 2015 Jul;17(7):841-2. doi: 10.1038/ncb3198.


The eukaryotic cell uses two complex machineries to degrade unwanted proteins. The first is the ubiquitin-proteasome system and the second is autophagy. A new study contributes to our understanding of how the two systems interconnect to coordinate protein degradation.

Publication types

  • Comment

MeSH terms

  • Adaptor Proteins, Signal Transducing / metabolism*
  • Animals
  • Arginine / metabolism*
  • Autophagy*
  • Endoplasmic Reticulum / metabolism*
  • Heat-Shock Proteins / metabolism*
  • Humans


  • Adaptor Proteins, Signal Transducing
  • Heat-Shock Proteins
  • Arginine