Rubicon swaps autophagy for LAP

Nat Cell Biol. 2015 Jul;17(7):843-5. doi: 10.1038/ncb3197.

Abstract

Phagocytic cells engulf their prey into vesicular structures called phagosomes, of which a certain proportion becomes demarcated for enhanced maturation by a process called LC3-associated phagocytosis (LAP). Light has now been shed on the molecular requirements of LAP, establishing a central role for the protein Rubicon in the immune response to Aspergillus fumigatus.

Publication types

  • Comment

MeSH terms

  • Animals
  • Autophagy*
  • Female
  • Intracellular Signaling Peptides and Proteins / metabolism*
  • Male
  • Membrane Glycoproteins / metabolism*
  • Microtubule-Associated Proteins / metabolism*
  • NADPH Oxidases / metabolism*
  • Phagocytosis*

Substances

  • Intracellular Signaling Peptides and Proteins
  • Membrane Glycoproteins
  • Microtubule-Associated Proteins
  • NADPH Oxidases