Polymorphism of UGT1A1*28 (TA)7 and Liver Damage in Hepatitis B Virus-Positive Patients in Albania

Genet Mol Res. 2015 May 18;14(2):5221-8. doi: 10.4238/2015.May.18.13.

Abstract

Hepatitis B virus (HBV) is the infectious agent of both acute and chronic hepatitis. HBV exists in multiple genotypic variants that differ in their capacity to become persistent chronic infections and in their clinical manifestations, including hepatocellular carcinoma. The 8 genotypes (A-H) of HBV show a specific worldwide geographic distribution and are correlated with different disease course, severity, and response to therapy. We isolated DNA from 75 HBV-positive blood donors, chosen randomly from the database of the National Blood Bank in Tirana, to specifically analyze the UGT1A1 polymorphism to determine its correlations with bilirubin levels and liver function. The large number of subjects who were HBV-positive carriers of heterozygosis or homozygosis for the UGT1A1*28 (TA)7 polymorphism suggests that these individuals may be more susceptible to cancer and should follow a strict regime of prevention.

MeSH terms

  • Albania
  • Blood Banks
  • Blood Donors
  • Carcinoma, Hepatocellular / blood
  • Carcinoma, Hepatocellular / genetics*
  • Carcinoma, Hepatocellular / pathology
  • DNA, Viral / genetics
  • Female
  • Genotype
  • Glucuronosyltransferase / genetics*
  • Hepatitis B / genetics
  • Hepatitis B / virology
  • Hepatitis B Surface Antigens / blood
  • Hepatitis B virus / genetics
  • Hepatitis B virus / pathogenicity
  • Humans
  • Liver / injuries
  • Liver / virology
  • Liver Cirrhosis / blood
  • Liver Cirrhosis / genetics*
  • Liver Cirrhosis / virology
  • Liver Neoplasms / blood
  • Liver Neoplasms / genetics*
  • Liver Neoplasms / pathology
  • Male
  • Middle Aged

Substances

  • DNA, Viral
  • Hepatitis B Surface Antigens
  • UGT1A1 enzyme
  • Glucuronosyltransferase