Competition, inhibition, and critical periods of cortical plasticity

Curr Opin Neurobiol. 2015 Dec;35:44-8. doi: 10.1016/j.conb.2015.06.006. Epub 2015 Jun 28.


Maturation of cortical inhibition just after eye opening is a necessary precedent for the emergence of competitive, experience-dependent ocular dominance plasticity in the visual cortex. What inhibition is doing in this context, though, is not clear. Here I outline new hypotheses on the roles of somatic and dendritic inhibition in the opening and closure of critical periods, and their roles in the competitive processes therein.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Cerebral Cortex / physiology*
  • Dominance, Ocular / physiology*
  • Humans
  • Neural Inhibition / physiology*
  • Neuronal Plasticity / physiology*
  • Vision, Binocular / physiology*
  • Vision, Monocular / physiology*